Published: 30 April, 2020 | Volume 4 - Issue 1 | Pages: 005-013
Figure 1:
Schematic of major clearance systems in (A,B,C,F) the brain and (D,E,F) the eye. (A,B,C) are representations of the IPAD and glymphatic pathways; (A) is a cross-section of an arteriole and represents CSF flow (cyan arrows) from the SAS into the peri-arterial space, as well as ISF flow (green- arrows) through the smooth muscle- basement membranes; (B) is a cross-section of an arteriole transitioning into a capillary, where CSF exits the peri-arterial space via AQP4 water- channels (purple) located on the astrocytic endfeet before mixing with ISF (cyan green arrow) and entering the smooth muscle basement -membranes; (C) is a coronal cross-section through the head and represents the glymphatic -pathway, dorsal mLVs, and CSF flow through an AG. CSF flows from the SAS into peri-arterial spaces before flowing intothe brain parenchyma via AQP4 channels, mixing with ISF, and then entering the perivenous- space for drainage via a convective flow.
Read Full Article HTML DOI: 10.29328/journal.icci.1001014 Cite this Article Read Full Article PDF
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